Histamine, histamine H 3 receptor, and alcohol use disorder
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چکیده
منابع مشابه
JPET # 170928 1 Histamine and H 3 receptor in alcohol - related behaviors
Data from rat models for alcohol preference and histidine decarboxylase knockout (HDC KO) mice suggest that brain histamine regulates alcohol-related behaviors. Histamine levels are higher in alcoholpreferring than alcohol non-preferring rat brains, and expression of histamine H3 receptor is different in key areas for addictive behavior. Histamine H3 receptor inverse agonists decrease alcohol r...
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The histamine H3 receptor has been identified in the rat brain as a presynaptic autoreceptor inhibiting histamine synthesis and release. Following its recent cloning, more than fifteen years later, the existence of isoforms, species pharmacological differences and the high constitutive activity of the receptor were established. All these molecular findings have to be taken into account for the ...
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Histamine intolerance results from a disequilibrium of accumulated histamine and the capacity for histamine degradation. Histamine is a biogenic amine that occurs to various degrees in many foods. In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity. Diamine oxidase (DAO) is the main ...
متن کاملHistamine and H3 receptor in alcohol-related behaviors.
Data from rat models for alcohol preference and histidine decarboxylase knockout (HDC KO) mice suggest that brain histamine regulates alcohol-related behaviors. Histamine levels are higher in alcohol-preferring than in alcohol-nonpreferring rat brains, and expression of histamine H(3) receptor (H(3)R) is different in key areas for addictive behavior. H(3)R inverse agonists decrease alcohol resp...
متن کاملIncreased brain histamine in an alcohol-preferring rat line and modulation of ethanol consumption by H(3) receptor mechanisms.
The histaminergic system is thought to regulate brain reward, but the exact mechanisms are poorly understood. This study aims to reveal the pathophysiological differences in the brain histaminergic system between selectively outbred alcohol-preferring AA and alcohol-avoiding ANA rats by using a combination of biochemical, immunohistochemical, and molecular biological methods. We also want to te...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2019
ISSN: 0007-1188,1476-5381
DOI: 10.1111/bph.14634